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   제목   Intraprocedure contrast enhanced ultrasound: The value in assessing the effect of ultrasound-guided high intensity focused ultrasound ablation for uterine fibroids.
   작성자   관리자     작성일   2015-12-28
   이메일       조회수   551
   첨부파일 없음 없음 없음
 
Ultrasonics. 2015 Apr;58:123-8. doi: 10.1016/j.ultras.2015.01.005. Epub 2015 Jan 17.


Intraprocedure contrast enhanced ultrasound: The value in assessing the effect of ultrasound-guided high 
intensity focused ultrasound ablation for uterine fibroids.


Peng S, Hu L, Chen W, Chen J, Yang C, Wang X, Zhang R, Wang Z, Zhang L.




State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of 
Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, College of 
Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China.
Clinical Center for Tumor Therapy of 2nd Affiliated Hospital of Chongqing Medical University, 74 Linjiang 
Road, Chongqing 400010, China.
HIFU Center for Tumor Therapy of 1st Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, 
Chongqing 400016, China.
State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of 
Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, College of 
Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China. Electronic address: 
wangzb@cqmu.edu.cn.
State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of 
Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, College of 
Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China. Electronic address: 
lianwzhang@yahoo.com.




PURPOSE: To investigate the value of microbubble contrast-enhanced ultrasound (CEUS) in evaluating the 
treatment response of uterine fibroids to HIFU ablation.



MATERIALS AND METHODS: Sixty-eight patients with a solitary uterine fibroid from the First Affiliated 
Hospital of Chongqing Medical University were included and analyzed. All patients underwent pre- and post-
treatment magnetic resonance imaging (MRI) with a standardized protocol, as well as pre-evaluation, 
intraprocedure, and immediate post-treatment CEUS. CEUS and MRI were compared by different radiologists.



RESULTS: In comparison with MRI, CEUS showed that the size of fibroids, volume of fibroids, size of non-
perfused regions, non-perfused volume (NPV) or fractional ablation (NPV ratio) was similar to that of MRI. In 
terms of CEUS examination results, the median volume of fibroids was 75.2 (interquartile range, 34.2-127.3) cm
(3), the median non-perfused volume was 54.9 (interquartile range, 28.0-98.1) cm(3), the mean fractional 
ablation was 83.7±13.6 (range, 30.0-100.0)%. In terms of MRI examination results, the median volume of 
fibroids was 74.1 (interquartile range, 33.4-116.2) cm(3). On the basis of contrast-enhanced T1-weighted 
images immediately after HIFU treatment, the median non-perfused volume was 58.5 (interquartile range, 
27.7-100.0) cm(3), the average fractional ablation was 84.2±14.2 (range, 40.0-100.0)%.


CONCLUSIONS: CEUS clearly showed the size of fibroids and the non-perfused areas of the fibroid. Results from 
CEUS correlated well with results obtained from MRI.


PMID: 25627929



출처: ?http://www.ncbi.nlm.nih.gov/pubmed/?term=25627929





초음파조영제 하이푸시술: 자궁근종에 대한 하이푸절제의 효과의 평가

목적: 하이푸절제에 자궁근종 치료의 반응을 평가하는 초음파조영제의 가치를 조사하기 위함



재료와 방식: ?충칭의과대학 제1부속병원에서 자궁근종을 가진 68명이 분석 대상이 되었습니다. 모든 환자들은 치료전후에 표준프로토콜
로 MRI검사를 받았으며 치료전, 치료중, 치료후 초음파조영제검사를 받았습니다. 초음파조영제검사와 MRI검사는 다른 영상의학과 의사
에 의해 비교 되었습니다. ?



결과: MRI와 비교하여 CEUS는 근종의 크기, 근종의 볼륨, 비관류영역, 비관류용적 또는 부분적 절제는 MRI와 비슷하였습니다. CEUS검
사 결과상 자궁근종의 볼륨의 중앙값은 75.2cm3, 비관류용적의 중앙값은 54.9cm3, 평균 부분적 절제는 83.7%였습니다. MRI검사 결과
상 자궁근종의 볼륨의 중앙값은 74.1cm3였습니다. 하이푸 직후의 조영증강 T1-강조 MRI영상에 비관류용적의 중앙값은 58.5cm3, 평균 
부분적 절제는 84.2%였습니다.?



결론: CEUS는 자궁근종의 크기와 비관류영역을 뚜렷하게 보여줍니다. CEUS는 MRI로부터 획득된 결과와 서로 밀접하게 연관 되었습니다.


     
 
         

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