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   제목   Effect of Biological Characteristics of Different Types of Uterine Fibroids, as Assessed with T2-Weighted Magnetic Resonance Imaging, on Ultrasound-Guided High-Intensity Focused Ultrasound Ablation.
   작성자   관리자     작성일   2015-12-28
   이메일       조회수   229
   첨부파일 없음 없음 없음
 
Ultrasound Med Biol. 2014 Dec 23.





Effect of Biological Characteristics of Different Types of Uterine Fibroids, as Assessed with T2-Weighted 
Magnetic Resonance Imaging, on Ultrasound-Guided High-Intensity Focused Ultrasound Ablation.




Zhao W, Chen J, Chen W.



 State Key Laboratory of Ultrasound Engineering in Medicine, Cofounded by Chongqing and the Ministry of 
Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, College of 
Biomedical Engineering, Chongqing Medical University, Chongqing, China (W.-P.Z., J.-Y.C., W.-Z.C.); and 
Clinical Center for Tumor Therapy, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 
China (W.-Z.C.). Dr Zhao is currently with the Department of Interventional Ultrasound, Chinese PLA General 
Hospital, Beijing, China.
State Key Laboratory of Ultrasound Engineering in Medicine, Cofounded by Chongqing and the Ministry of 
Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, College of 
Biomedical Engineering, Chongqing Medical University, Chongqing, China (W.-P.Z., J.-Y.C., W.-Z.C.); and 
Clinical Center for Tumor Therapy, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 
China (W.-Z.C.). Dr Zhao is currently with the Department of Interventional Ultrasound, Chinese PLA General 
Hospital, Beijing, China. chenwz@haifu.com.cn.




 The aims of this study were to assess the effects of the biological characteristics of different types of 
uterine fibroids, as assessed with T2-weighted magnetic resonance imaging (MRI), on ultrasound-guided high-
intensity focused ultrasound (USgHIFU) ablation. Thirty-five patients with 39 symptomatic uterine fibroids 
who underwent myomectomy or hysterectomy were enrolled. Before surgery, the uterine fibroids were subdivided 
into hypo-intense, iso-intense, heterogeneous hyper-intense and homogeneous hyper-intense categories based on 
signal intensity on T2-weighted MRI. Tissue density and moisture content were determined in post-operative 
samples and normal uterine tissue, the isolated uterine fibroids were subjected to USgHIFU, and the extent of 
ablation was measured using triphenyltetrazolium chloride. Hematoxylin and eosin staining and sirius red 
staining were undertaken to investigate the organizational structure of the uterine fibroids. Estrogen and 
progesterone receptor expression was assayed via immunohistochemical staining. The mean diameter of uterine 
fibroids was 6.9 ± 2.8 cm. For all uterine fibroids, the average density and moisture content were 10.7 ± 0.7 
mg/mL and 75.7 ± 2.4%, respectively; and for the homogeneous hyper-intense fibroids, 10.3 ± 0.5 mg/mL and 
76.6 ± 2.3%. The latter subgroup had lower density and higher moisture content compared with the other 
subgroups. After USgHIFU treatment, the extent of ablation of the hyper-intense fibroids was 102.7 ± 42.1 
mm2, which was significantly less than those of the hypo-intense and heterogeneous hyper-intense fibroids. 
Hematoxylin and eosin staining and sirius red staining revealed that the homogeneous hyper-intense fibroids 
had sparse collagen fibers and abundant cells. Immunohistochemistry results revealed that estrogen and 
progesterone receptors were highly expressed in the homogeneous hyper-intense fibroids. This study revealed 
that lower density, higher moisture content, sparse collagen fibers, abundant cells and overexpression of 
estrogen and progesterone receptors are important biological characteristics that resulted in poor efficacy 
in the treatment of homogeneous hyper-intense fibroids.




PMID: 25154933




출처: http://www.ncbi.nlm.nih.gov/pubmed/25542494






하이푸 절제에 있어 T2-강조 MRI로 평가된 다른 타입 자궁근종의 생물학적 형질의 효능



Zhao W, Chen J, Chen W.



이 연구의 목적은 하이푸절제에 있어 T2-강조 자기공명영상으로서 평가된 다른 타입의 자궁근종의 생물학적 형질의 효과를 평가하기 위함
입니다.? 35명의 자궁근종절제술 또는 자궁절제술을 받은  자궁근종 환자가 등록되었습니다. 수술 전에 자궁근종은 T2-강조 MRI에 기초하
여 저음영, 등음영, 이질적 고음영, 동종의 고음영 범주로 다시 나누었습니다. 조직 밀도와 함수율은 수술 후 샘플과 정상적 자궁조직으
로 알아냈고, 분리된 자궁근종은 하이푸에 영향을 받았고, 절제의 정도는 3페닐4졸륨염화물을 이용하여 측정되었습니다. 헤마톡실린과 에
오신염색과 시리어스레드염색으로 자궁근종의 조직 구조를 조사하였습니다. 에스트로겐과 프로게스테론 수용체 발현은 면역조직화학염색
을 통해 시험분석되었습니다. 평균 자궁근종 직경은 6.9 ± 2.8 cm이었습니다. 모든 자궁근종에 대한 평균 밀도와 함수율은 각각 10.7 
± 0.7 mg/mL과 75.7 ± 2.4%였고, 동종의 고음영 근종은 10.3 ± 0.5 mg/mL과 76.6 ± 2.3%이었습니다. 최후 하위그룹은 다른 하위
그룹과 비교하여 더 낮은 밀도와 높은 수분율을 보였습니다. 하이푸시술 후 고음영 근종의 절제범위는 저음영과 이질적 고음영 근종들보
다 유의하게 낮은 102.7 ± 42.1 mm2였습니다. ?헤마톡실린과 에오신염색과 시리어스레드염색으로 동종의 고음영 근종이 희박한 콜라겐 
섬유와 풍부한 세포를 가졌다는 것을 밝혔습니다. 면역조직화학검사 결과는 에스트로겐과 프로게스테론 수용체가 동종의 고음영 근종에서 
높게 발현되었다는 것을 밝혔습니다. 이 연구는? 저밀도, 고함수율, 희박한 콜라겐 섬유, 풍부한 세포 그리고 에스트로겐과 프로게스테론
의 과발현이 동종의 고음영 근종의 치료에 있어 낮은 치료 효능를 보이는 중요한 생물학적 형질이다는 것을 밝혔습니다.? 

     
 
         

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