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   제목   Contrast-enhanced ultrasound for evaluation of high-intensity focused ultrasound treatment of benign uterine diseases: retrospective analysis of contrast safety.
   작성자   관리자     작성일   2016-01-20
   이메일       조회수   448
   첨부파일 없음 없음 없음
 
Medicine (Baltimore). 2015 Apr;94(16):e729. 


Contrast-enhanced ultrasound for evaluation of high-intensity focused ultrasound treatment of benign uterine 
diseases: retrospective analysis of contrast safety.



Cheng CQ, Zhang RT, Xiong Y, Chen L, Wang J, Huang GH, Li KQ, Zhang L, Bai J.



From State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of 
Science and Technology (CQC, RTZ, JW, GHH, KQL, LZ, JB), Chongqing Key Laboratory of Ultrasound in Medicine 
and Engineering, College of Biomedical Engineering, Chongqing Medical University; Department of Obstetrics 
and Gynecology (RTZ), Fuling Central Hospital; Department of Obstetrics and Gynecology (YX, LC, KQL), 
Chongqing Haifu Hospital; Department of Obstetrics and Gynecology (JW), Three Gorges Central Hospital, 
Chongqing; and Department of Obstetrics and Gynecology (GHH), Suining Central Hospital, Sichuan, China.


As a noninvasive treatment technique, ultrasound-guided high-intensity focused ultrasound (HIFU) has been 
considered as a routine treatment for uterine fibroids and adenomyosis in China. Contrast-enhanced ultrasound 
(CEUS) has been proposed as another option to assess the treatment efficacy during HIFU treatment. The aim of 
this investigation is to evaluate the adverse effects of HIFU ablation for benign uterine diseases in a group 
of patients studied with ultrasound contrast agent (UCA), in comparison with a group of patients not exposed 
to UCA. From November 2010 to December 2013, 2604 patients with benign uterine diseases were treated with 
HIFU. Among them, 1300 patients were exposed to an UCA, whereas 1304 patients were not.During HIFU procedure, 
the incidences of leg pain, sacral/buttock pain, groin pain, treatment area pain, and the discomfort "hot" 
sensation on skin were higher in the patients who were exposed to SonoVue (Bracco, Milan, Italy) than those 
who were not (20.5% vs 11.7%, 52.5% vs 42.3%, 6.5% vs 4.5%, 68.9% vs 55.4%, and 48.1% vs 42.9%, 
respectively). Among the postoperative adverse effects, the incidence of lower abdominal pain was 
significantly higher in patients who were exposed to an UCA than those who were not (51.2% vs 39.9%, P
0.05). Two patients who were exposed to an UCA had acute renal function failure. In conclusion, UCA may 
increase the incidences of some common HIFU-related adverse effects during HIFU treatment for benign uterine 
diseases, but most of which were acceptable and self-limited. After HIFU treatment, renal function should be 
monitored in patients with a history of hypertension or taking nonsteroidal anti-inflammatory drugs.

 
PMID: 25906100 

 

출처: http://www.ncbi.nlm.nih.gov/pubmed/25906100

[출처] Contrast-enhanced ultrasound for evaluation of high-intensity focused ultrasound treatment of benign 
uterine diseases: retrospective analysis of contrast safety.

     
 
         

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